Everything You Need to Know About Cyclobenzaprine Flexeril for Sleep
This page will go over its side effects, drug interactions, and treatment for misuse. The efficacy of FLEXERIL 5 mg was demonstrated in two seven-day, double-blind, controlled clinical trials enrolling 1405 patients. One study compared FLEXERIL 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo. Primary endpoints for both trials were determined by patient-generated data and included global impression of change, medication helpfulness, and relief from starting backache. Each endpoint consisted of a score on a 5-point rating scale (from 0 or worst outcome to 4 or best outcome). Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Aug 2023) and others. Flexeril is used together with rest and physical therapy to treat skeletal muscle conditions such as pain, injury, or spasms.
- Dialysis is probably of no value because of low plasma concentrations of the drug.
- However, physical therapy tends to outperform chiropractic care in the cases of back pain and knee pain.
- Cyclobenzaprine is not approved or recommended for treating anxiety but it does cause some of the same side effects as other anti-anxiety medications including sleepiness and drowsiness.
- There are over 12,000 people in the U.S who will go to the emergency room looking to be treated for Flexeril overdose.
- An overactive thyroid, heart disease, heart failure, or a recent heart attack could all increase your risk of experiencing serious side effects when taking cyclobenzaprine.
So, please don’t discount the need for professional treatment if you’re addicted to Flexeril. If you attempt to quit using it on your own, you put yourself at risk for an overdose. Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. Always discuss possible side effects with a healthcare professional who knows your medical history.
Muscle Spasm
Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated. In three of these studies there was a significantly greater improvement with FLEXERIL than with diazepam, while in the other studies the improvement following both treatments was comparable. Cyclobenzaprine caused slight to moderate increase in heart rate in animals. Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models. Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems.
According to the National Institute on Drug Abuse or NIDA, more than 50 million Americans aged 12 and over have reportedly misused a prescription drug at least once in their life. There were 25.2 million prescriptions can flexeril cause depression wrote in 2011 that included cyclobenzaprine such as Flexeril. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating.
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Signs of Flexeril overdose include agitation, trouble speaking or moving, and hallucinations (15). The physical effects of Flexeril include relaxation to the muscles. If a person is experiencing muscular pain from an injury, Flexeril controls the spasms that result in pain.
What should I tell my care team before I take this medication?
It can also enhance the effects of agents with CNS depressant activity. Older adults appear to have a higher risk for CNS-related adverse reactions, such as hallucinations and confusion, when using cyclobenzaprine. Withdrawal symptoms have been noted with the discontinuation of chronic cyclobenzaprine use.
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Unlike a handful of other muscle relaxers such as carisoprodol (Soma), it’s not currently controlled under the Controlled Substances Act (9). Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
How to take Cyclobenzaprine (Flexeril)?
It is structurally similar to the tricyclic antidepressants and adverse effects similar to those seen with the tricyclic antidepressants are therefore to be expected. Cyclobenzaprine is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries. Cyclobenzaprine is in a class of medications called skeletal muscle relaxants. It works by acting in the brain and nervous system to allow the muscles to relax.
The primary adverse side effects of cyclobenzaprine are related to the central nervous system (CNS), and include drowsiness, dizziness, and nervousness (10). Some patients also report gastrointestinal issues (stomach problems) like nausea, vomiting, constipation, and loss of appetite, as well as dry mouth (11, 12). Dangerous consequences can come from Flexeril abuse, especially when mixed with other drugs like alcohol or opioids.